Top 10 Toxic Substances Pets Are Exposed to at Home, According to the ASPCA

A 2025 report from the American Society for the Prevention of Cruelty to Animals (ASPCA) reveals that the ASPCA’s Animal Poison Control Center (APCC) received calls regarding more than 376,000 items’ potential toxicity.

Although this number seems high, it’s a slight decline from the previous year. In 2024, the APCC responded to over 451,000 calls from pet parents whose peckish pets, from cats and dogs to snakes and peacocks, were a little too curious.

Year over year, some things remain the same: certain household items, like over-the-counter medications or different plants and fungi, remain irresistible to pets. So before curiosity literally kills the cat — and before any pet on your watch consumes something they shouldn’t — you’ll want to educate yourself about which substances your pet should not go near.

As Dr. Tina Wismer, the senior director of the ASPCA Animal Poison Control Center, explains to us, the return to in-office work over the past few years has had an unexpected impact.

“We’ve become a little more lax in our protective measures,” Dr. Wismer says. “We think, ‘Well, the dogs have been great while I’ve been home.’ Then we go back to work and the dogs are like, ‘Yes!’” Read on to learn more about the top pet toxins of 2025, and how you can prevent your pet from ingesting them when you’re not around.

The top 10 pet toxins of 2025

We talked to Dr. Wismer about the top 10 pet toxins — and how you can keep your pet safe.

10. Recreational drugs

Your cat (or dog!) can have all the catnip they want, but the other green stuff’s a no-no. “We know that over the past few years, as marijuana has been legalized for either recreational or medical use, we’ve seen increases in pets getting into it,” Dr. Wismer says. THC can cause a variety of nasty symptoms in pets, including tremors, vomiting, and disorientation.

The number of marijuana-related calls have leveled out, she adds, but there’s a new culprit rising in the ranks: shrooms — particularly a variety called Amanita muscaria. “They’ve been putting this into chocolate bars,” Dr. Wismer says. This makes them doubly dangerous, since chocolate comes with its own risks (no spoilers, but more on this later).

She adds: “These are not regulated at all by anyone, and because a lot of them are chocolate, dogs are thrilled to get into them.” They can cause more severe symptoms than marijuana, including tremors and seizures. In 2025, recreational drug exposure — marijuana, mushrooms, and more — amounted to 1.9 percent of all calls to the APCC.

9. Insecticides

If you’re using insecticides, the ASPCA recommends diluting the product to the lowest percentage needed to work, keeping your pet away from insecticide while it dries, and locking the product up when it’s not in use. Make sure to read the label to learn about the correct dilution procedure — insecticides contributed to 3.8 percent of all pet poison exposures in 2025.

8. Household products

Dr. Wismer explains that toxic cleaning products and laundry detergent are the most commonly reported household products that pets ingest. They should be stored far out of a pet’s reach. Paint, too, can be a danger.

7. Rodenticides

Needless to say, rat poison is super dangerous for your pets. The ASPCA recommends keeping your cats and dogs out of affected areas and regularly checking that bait hasn’t moved. 7.5 percent of all toxin exposures in 2025 could be traced back to rodent bait and poisons.

6. Plants and fungi

Happily, the number of overall plant exposures has dropped from between 2024 to 2025, but it still covered 7.5 percent of all exposures last year. Both dogs and cats should be shielded from poisonous plants, but our feline friends are especially likely to chow down on some leaves — however high we try to store them. “With cats we get more calls about plants than anything else. Especially bouquets,” Dr. Wismer says. “Unfortunately, lilies are very common in bouquets, and they can be deadly to cats.”

5. Veterinary products

To make them more appealing to dogs and cats, lots of veterinary medications are formulated to be pretty yummy. The downside of that is that your pet might want to go back to snack on more than their prescribed dosage.

Dr. Wismer explains that chewable medications for arthritis and urinary incontinence are the most common culprits. “Overdoses of that medication can cause high blood pressures and seizures,” she says. “Since they’re tasty, we want to keep them away from pets.”

4. Chocolate

It’s a great tragedy, but chocolate is a classic doggie no-no — and it’s toxic for cats, too. Chocolate can cause symptoms including vomiting, diarrhea, and elevated blood pressure; in severe cases, ingesting the snack can lead to a seizure, coma, or death. In 2025, chocolate made up 13.6 percent of all toxic substance exposures called in to the APCC.

3. Human prescription medications

No, they’re not raiding your medical cabinet — but they are gobbling up any dropped or unsupervised pills. Screw those childproof caps on tight. Heart medications, antidepressants, and ADHD medications were the top three most-ingested types of human medication last year.

2. Human food and drinks

There are plenty of snacks you can safely share with your pet, but there are also a lot of dangerous human foods out there, including some human favorites like onions, garlic, grapes, avocado, and caffeine. In total, 16.4 percent of pet poison control calls in 2025 were related to human foods and drink.

1. Over the counter medications, vitamins, and supplements

Drumroll: The most common call is for over the counter medications, vitamins, and supplements, like good old (toxic) Ibuprofen and Tylenol, amounting to 16.9 percent of APCC calls last year. 2025 also saw the rise of a new variation on this theme: the rising popularity of skincare products, including masks and creams, led to a number of these calls last year.

How to keep your pet safe

Yes, that’s a scary list of everyday household items. Luckily, there are plenty of ways to keep your pet out of harm’s way. “It is all about prevention,” Dr. Wismer says.

It’s especially vital to protect high-energy puppies and kittens. “They’re much more agile. They’re going to get into things that you don’t expect,” Dr. Wismer says. “Puppy proofing or pet proofing your house before you bring them on board is the best thing to do.”

When it comes to puppy proofing, Dr. Wismer recommends keeping things (especially tempting, tasty treats) off the counters and out of your pet’s reach. She also advocates for using tools like baby gates and locks on cabinets; crate training a pup can help, too.

Dr. Wismer stresses that all members of the household have to be on board — whether those are roommates, partners, or kids. Everyone will have to stay alert and keep the pet’s safety at the top of their mind when dealing with toxic substances, from obvious dangers like rat poison to everyday snacks like grapes. “It’s a lot of training people as opposed to training pets,” she says.

If your pet gets into trouble anyway (they can be crafty, after all), the ASPCA Animal Poison Control Center is available 24/7, 365 days a year. You can call 888-426-4435 for immediate assistance.